The design of the girls were used a cartoony-like form, and they have fingers, toes, eyebrows, ears and noses (like the Run-of-the-Mill Girls from the original show's episode "Oops, I Did It Again").
The new design of the city of Townsville is inspired by Cartoon Network's third era from 2004 until 2006.
This show is similar to the DC Nation shorts and the PPG episodes from 2002-2005 (along with The Powerpuff Girls Movie).
The Cartoon Network characters were showing up on every episode.
The end of the episode whose summary and plot is completely like the episode "The Mane Event", after the credits, instead of the usual closing logos, an ABC TV Australia ident 1997 appears, but is re-edited to show Blossom (with her bad mangled-up haircut) dropping by.
Bubbles' new voice is a same as the Cartoon Network game FusionFall.
Him's new voice is a same as the Cartoon Network game FusionFall.
This is the third time for Bullet (from the original PPG show) appears.
This show should not be confused with Cartoon Network's 2016 reboot of The Powerpuff Girls.